What is this test?
Anti-CCP IgG antibodies target citrullinated proteins. They may support an assessment for rheumatoid arthritis when compatible joint symptoms are present.
Why might it be ordered?
- For pain, swelling and morning stiffness of the joints.
- To supplement RF and clinical examination or to evaluate negative RF.
What sample is needed?
A healthcare professional collects a venous blood sample. Depending on the method, the laboratory uses serum or plasma.
How should you prepare?
Tell the laboratory about all medicines, hormone treatments, vitamins and supplements you take. Do not stop or change treatment unless your clinician tells you to. Follow any instructions about fasting and the time of collection.
How should you understand the result?
A positive Anti-CCP IgG result increases the likelihood of rheumatoid arthritis when compatible symptoms are present, but it is not a diagnosis on its own. A positive result means the tested antibodies were detected, but it does not establish a diagnosis on its own. A negative result does not rule out every autoimmune condition.
Sources and editorial status
This patient-facing text is an editorial draft. It should be approved by a laboratory physician before official publication.